[Sodium nucleinate increase of nonspecific macroorganism resistance to conditionally pathogenic and pathogenic microorganisms].

Abstract

Sodium nucleinate significantly increased the non-specific resistance of mice to E. coli O26, Ps. vulgaris, Ser. marcesens, Ps. aeruginosa, Kl. ozaenae and their associations and total resistance also accompanied by a significant decrease in the number of the bacteria in the spleen and blood, the total number of the cells in the peritoneal exudate and the number of the cells adhering to the glass (macrophages). The preparation is a low molecular RNA consisting mainly of fraction 3S and a small amount of fraction 4S. It contains 1.5 per cent of protein and 2 per cent of DNA and does not contain any polysaccharides. Repeated purification of sodium nucleinate lowering the levels of the admixtures 5 times did not change its efficacy. The low molecular RNA of the rat liver (4S) had a pronounced stimulating activity. On infection of the host stimulated with sodium nucleinate, formation of the post-infection immunity was not decreased.

• Authors: A A Barsukov, V M Zemskov, V R Sobolev
• Journal: Antibiotiki (Antibiotiki) Vol. 23 Issue 6 Pg. 520-6 (Jun 1978) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Povyshenie nespetsificheskoĭ rezistentnosti makroorganizma k uslovno-patogennym i patogennym mikroorganizmam nukleinatom natriia.
• PMID: 677839 (Publication Type: Journal Article)

Chemical References

• Nucleic Acids
• RNA
• DNA
• sodium nucleinate

Topics

• Animals
• Bacteria (pathogenicity)
• Bacterial Infections (prevention & control)
• DNA (therapeutic use)
• Drug Evaluation, Preclinical
• Immunity, Innate (drug effects)
• Mice
• Nucleic Acids
• RNA (therapeutic use)
• Stimulation, Chemical
• Time Factors