Comparison of the activity of some fasciolicides against immature liver fluke in calves.

Abstract

The anthelmintic activities of nitroxynil, closantel and rafoxanide were tested in cattle against six- and eight-week-old infections of Fasciola hepatica. Administered by subcutaneous injection, nitroxynil and rafoxanide at dose rates of 10 and 3 mg/kg bodyweight respectively were 88.5 and 36.1 per cent effective in eliminating a six-week-old infection of F hepatica and 85.8 and 60.4 per cent effective against an eight-week-old infection. Closantel administered by intramuscular injection at a dose rate of 2.5 mg/kg bodyweight was 60.0 per cent effective against an eight-week-old F hepatica infection.

• Authors: S E Dobbins, A C Wellington
• Journal: The Veterinary record (Vet Rec) Vol. 111 Issue 9 Pg. 177-8 (Aug 28 1982) ISSN: 0042-4900 [Print] England
• PMID: 6753310 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Anthelmintics
• Salicylanilides
• Rafoxanide
• Nitroxinil
• closantel

Topics

• Animals
• Anthelmintics (therapeutic use)
• Cattle
• Cattle Diseases (drug therapy, parasitology)
• Clinical Trials as Topic (veterinary)
• Fasciola hepatica
• Fascioliasis (drug therapy, parasitology, veterinary)
• Liver (parasitology)
• Nitroxinil (therapeutic use)
• Rafoxanide (therapeutic use)
• Salicylanilides (therapeutic use)