Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.

Abstract

3,2'-Dimethyl-4-aminobiphenyl and 3,2'-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with 3,2'-dimethyl-4-aminobiphenyl, 24 animals had bladder tumors. In the group treated with 3,2'-dimethyl-4-nitrosobiphenyl 25 animals had subcutaneous tumors and 2 had bladder tumors. These results indicate that 3,2'-dimethyl-4-nitrosobiphenyl is a potent locally acting carcinogen. Total doses of 99 mmol/kg of aniline, o-toluidine, nitrosobenzene, or o-nitrosotoluene administered by subcutaneous injection failed to induce tumors.

• Authors: S S Hecht, K El-Bayoumy, A Rivenson, E S Fiala
• Journal: Cancer letters (Cancer Lett) Vol. 20 Issue 3 Pg. 349-54 (Oct 1983) ISSN: 0304-3835 [Print] Ireland
• PMID: 6627231 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Nitroso Compounds
• 3,2'-dimethyl-4-nitrosobiphenyl
• 2-nitrosotoluene
• nitrosobenzene

Topics

• Animals
• Carcinogens
• Cricetinae
• Male
• Mesocricetus
• Nitroso Compounds (toxicity)
• Urinary Bladder Neoplasms (chemically induced)