Radioactive-induced tumors by phosphorus-32 as colloidal compound.

Abstract

Chromic colloidal phosphate labeled with 32P, which has been proposed for the treatment of several articular diseases, was injected intra-articularly in the knee joint of adult Wistar rats. After a 270 days minimum latent period, tumors began to appear in the injected zone, to a 70% frequency. Ten lung metastases were detected. In five cases, squamous cell carcinomas were induced in the injected area. The relevance of a sound evaluation of the risk involved in treatments with radioactive isotopes, is discussed.

• Authors: A M Ubios, F S Silberman, R L Cabrini
• Journal: Cancer (Cancer) Vol. 51 Issue 9 Pg. 1605-9 (May 01 1983) ISSN: 0008-543X [Print] United States
• PMID: 6572544 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphorus Radioisotopes

Topics

• Animals
• Carcinoma, Squamous Cell (etiology)
• Hindlimb
• Injections, Intra-Articular
• Joint Diseases (etiology)
• Joints
• Lung Neoplasms (secondary)
• Male
• Neoplasms, Experimental (etiology)
• Neoplasms, Radiation-Induced (etiology, pathology)
• Osteosarcoma (etiology)
• Phosphorus Radioisotopes (adverse effects)
• Rats
• Rats, Inbred Strains