[Convulsions induced by kynurenine and quinolinic acid as a sensitive test for assessing the anticonvulsant activity of GABA-ergic preparations].

Abstract

Phenibut, sodium hydroxybutyrate and baclofen are selectively effective against seizures induced in mice by the endogenous metabolites of tryptophan, L-kynurenine and quinolinic acid. The seizures were not affected by the drugs in doses under study. Depakine and aminooxyacetic acid as well as diazepam and phenobarbital appeared the most effective against pentylenetetrazole seizures. GABA and muscimol administered intracerebroventricularly merely prolonged the latency of seizures. Dissimilarities in the GABA-ergic mechanisms of the anticonvulsant effects of the drugs under consideration are discussed.

• Authors: I P Lapin, I V Ryzhov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 95 Issue 4 Pg. 53-5 (Apr 1983) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Sudorogi, vyzyvaemye kinureninom i khinolinovoĭ kislotoĭ, kak chuvstvitel'nyĭ test dlia otsenki protivosudorozhnoĭ aktivnosti GAMK-ergicheskikh preparatov.
• PMID: 6299432 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Pyridines
• Quinolinic Acids
• Receptors, Cell Surface
• Receptors, GABA-A
• Kynurenine
• gamma-Aminobutyric Acid

Topics

• Animals
• Anticonvulsants (therapeutic use)
• Drug Evaluation, Preclinical (methods)
• Kynurenine (pharmacology)
• Male
• Mice
• Mice, Inbred Strains
• Pyridines (pharmacology)
• Quinolinic Acids (pharmacology)
• Reaction Time (drug effects)
• Receptors, Cell Surface (drug effects)
• Receptors, GABA-A
• Seizures (chemically induced, drug therapy)
• gamma-Aminobutyric Acid (metabolism)