Chemically induced porphyria: increased microsomal heme turnover after treatment with allylisopropylacetamide.

Abstract

Excessive induction of delta-aminolevulinic acid synthetase in rats after treatment with porphyria-inducing chemicals, such as allylisopropylacetamide, is accompanied by a decrease in microsomal heme and cytochrome P450 concentrations. Measurement of the radioactive decay after labeling of the heme moiety of submicrosomal particles shows increased breakdown of heme in rats treated with allylisopropylacetamide. The effects of allylisopropylacetamide on heme synthesis and heme turnover may be interrelated

• Authors: U A Meyer, H S Marver
• Journal: Science (New York, N.Y.) (Science) Vol. 171 Issue 3966 Pg. 64-6 (Jan 08 1971) ISSN: 0036-8075 [Print] United States
• PMID: 5538700 (Publication Type: Journal Article)

Chemical References

• Acetates
• Amides
• Cytochromes
• Levulinic Acids
• Tritium
• Heme
• Acyltransferases

Topics

• Acetates (pharmacology)
• Acyltransferases (biosynthesis)
• Amides (pharmacology)
• Animals
• Cytochromes (metabolism)
• Enzyme Induction
• Heme (biosynthesis, metabolism)
• Levulinic Acids (pharmacology)
• Male
• Microsomes, Liver (metabolism)
• Porphyrias (chemically induced, metabolism)
• Rats
• Tritium