N-acetyltransferase activity as a possible criterion in prognosing the anti-tumor effect of cyclophosphamide.

Abstract

The results obtained in the present study indicated that a reduction in the activity of N-acetyltransferase (EC 2.3.1.5) occurs in cyclophosphamide-treated mice with sarcoma 37. A difference in variations of the level of N-acetyltransferase activity in outbred mice with and without tumors was observed in cyclophosphamide-treated animals. It was established that the effect of cyclophosphamide on the activity of N-acetyltransferase depends on the initial level of the enzyme activity (phenotype of acetylation) as well as on the genotype which determines the N-acetyltransferase activity.

• Authors: L N Bulovskaya, A I Kolosov, R G Krupkin
• Journal: Oncology (Oncology) Vol. 36 Issue 3 Pg. 130-3 ( 1979) ISSN: 0030-2414 [Print] Switzerland
• PMID: 471424 (Publication Type: Journal Article)

Chemical References

• Cyclophosphamide
• Acetyltransferases

Topics

• Acetyltransferases (metabolism)
• Animals
• Cyclophosphamide (therapeutic use)
• Female
• Mice
• Mice, Inbred C3H
• Prognosis
• Sarcoma 37 (drug therapy, enzymology)