Abstract |
The efficacy of misoprostol (a synthetic analogue of prostaglandin E1) and cimetidine in the treatment of gastric ulcer was evaluated. Thirty-two patients with endoscopically proven gastric ulcer were randomized, in a double-blind manner, in one of three groups that received four daily doses of either misoprostol, 50 or 200 micrograms, or cimetidine, 300 mg. Ulcer healing was assessed endoscopically after 4 weeks of treatment. The three groups were fairly comparable in their alcohol and caffeine intake, previous ulcer history and ulcer size. A relatively high proportion of patients in the cimetidine-treated group was smokers. Only one patient was withdrawn from the study. On the misoprostol low dose, healing of the ulcer was observed in 20% of the patients. In contrast, healing on the high dose of misoprostol (70%) was not significantly different from that on cimetidine (73%). No important clinical side effects were observed in any of the patients. These results (part of a multicenter, international study) suggest that the divided daily dose of 800 micrograms misoprostol is safe and effective in the short-term treatment of gastric ulcer.
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Authors | A Fich, E Goldin, J Zimmerman, M Ligumsky, D Rachmilewitz |
Journal | Israel journal of medical sciences
(Isr J Med Sci)
Vol. 21
Issue 12
Pg. 968-72
(Dec 1985)
ISSN: 0021-2180 [Print] Israel |
PMID | 3937820
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Misoprostol
- Cimetidine
- Alprostadil
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Topics |
- Adolescent
- Adult
- Aged
- Alprostadil
(analogs & derivatives, therapeutic use)
- Cimetidine
(therapeutic use)
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Gastric Mucosa
(drug effects, metabolism)
- Gastroscopy
- Humans
- Male
- Middle Aged
- Misoprostol
- Random Allocation
- Smoking
- Stomach Ulcer
(drug therapy, pathology, physiopathology)
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