The topical effects of Wy-41,195 [2-cyano-3-(methylamino)phenylamino] oxoacetic acid, sodium salt and disodium cromoglycate in the rat passive eyelid anaphylaxis.

Abstract	Wy-41,195 demonstrated significant inhibitory effects (54-60%) when administered topically at 0.25-2% concentrations in a rat passive eyelid anaphylaxis assay. In contrast, topically applied disodium cromoglycate (DSCG) showed non significant inhibition at these concentrations. The potency of Wy-41,195 was more than 8 times greater than DSCG, and this compound may be an effective topical agent in man in preventing allergic and associated conditions.
Authors	R P Carlson, L O'Neill-Davis, A J Lewis
Journal	International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 76 Issue 1 Pg. 89-90 ( 1985) ISSN: 0020-5915 [Print] Switzerland
PMID	3917983 (Publication Type: Comparative Study, Journal Article)
Chemical References	Amino Acids (2-cyano-3-(methylamino)phenyl)oxoacetic acid Cromolyn Sodium Oxamic Acid
Topics	Administration, Topical Amino Acids Animals Cromolyn Sodium (administration & dosage, immunology) Eyelids Immunosuppression Therapy Oxamic Acid (administration & dosage, analogs & derivatives, immunology) Passive Cutaneous Anaphylaxis Rats Rats, Inbred Strains

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