Abstract |
The concentrations of dichlorprop and its leucine conjugate in serum and bile of rats have been determined at different periods after a single oral dosage of these compounds (30 or 300 mg/kg body weight). From the results it can be concluded that dichlorprop is excreted by active renal mechanisms resembling that described for 2,4,5-T. It is suggested that the leucinate is excreted more by the biliary route. Investigations of the liver demonstrate that both compounds are able to induce mixed function oxidases.
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Authors | H Beitz, U Banasiak, S Gericke, P Clausing |
Journal | Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
(Arch Toxicol Suppl)
Vol. 8
Pg. 259-63
( 1985)
ISSN: 0171-9750 [Print] Germany |
PMID | 3868352
(Publication Type: Journal Article)
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Chemical References |
- dichlorprop-leucine conjugate
- 2,4-Dichlorophenoxyacetic Acid
- Mixed Function Oxygenases
- Leucine
- dichlorprop
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Topics |
- 2,4-Dichlorophenoxyacetic Acid
(analogs & derivatives, metabolism, pharmacology, toxicity)
- Animals
- Bile
(analysis)
- Enzyme Induction
(drug effects)
- Kidney
(metabolism)
- Kinetics
- Leucine
(metabolism, pharmacology)
- Liver
(metabolism)
- Liver Function Tests
- Male
- Microsomes, Liver
(drug effects, enzymology)
- Mixed Function Oxygenases
(metabolism)
- Rats
- Rats, Inbred Strains
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