Comparative study on antitumor effect of cell-wall skeleton of Mycobacterium bovis BCG and Nocardia rubra, with reference to T-cell dependency and independency.

Abstract

Antitumor activity induced by the oil-attached cell-wall skeleton of Nocardia rubra (N-CWS) was compared with that of the oil-attached cell-wall skeleton of Mycobacterium bovis BCG (BCG-CWS) in syngeneic BALB/c tumor-host systems. In normal BALB/c mice (+/+), N-CWS exhibited stronger suppressive effect on syngeneic Br-1 and MCA tumors than did BCG-CWS. In athymic nude mice (nu/nu), BCG-CWS was as effective as N-CWS for the suppression of growth of such tumors. Suppressive effect of N-CWS treatment appears to be stronger to some extent in +/+ mice than in nu/nu mice. Immune spleen cells obtained from +/+ mice after footpad inoculation of MCA tumor cells mixed with N-CWS were effective in suppressing the MCA tumor growth, although those obtained from mice after inoculation of MCA tumor cells mixed with BCG-CWS did not exhibit a suppressive effect. This antitumor activity of immune spleen cells may be attributed to tumor-specific killer T cells. The differences of antitumor activities induced by these agents were discussed with reference to T-cell dependency and independency.

• Authors: E Yanagawa, K Yasumoto, M Ohta, K Nomoto, I Azuma, Y Yamamura
• Journal: Gan (Gan) Vol. 70 Issue 2 Pg. 141-6 (Apr 1979) ISSN: 0016-450X [Print] Japan
• PMID: 381087 (Publication Type: Comparative Study, Journal Article)

Chemical References

• BCG Vaccine
• Bacterial Vaccines

Topics

• Animals
• BCG Vaccine (immunology, therapeutic use)
• Bacterial Vaccines (immunology, therapeutic use)
• Cell Wall
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Mycobacterium bovis (ultrastructure)
• Neoplasms, Experimental (therapy)
• Nocardia (immunology, ultrastructure)
• T-Lymphocytes (immunology)