[Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland].

Abstract

Sclerosing mucoepidermoid carcinoma with stromal eosinophilia of thyroid gland is represented less than 100 cases in the world literature. We present a rare case of sclerosing mucoepidermoid carcinona with stromal eosinophilia in a 69-year-old woman who has been observed for multinodular goiter for more than 3 years. Cytological examination revealed a picture most of all corresponding to a malignant neoplasm (Bethesda V). The patient underwent a thyroidectomy. Pathomorphological examination revealed a neoplasm of mixed structure with foci of cribriform structures and squamous metaplasia with areas of keratinization. According to the IHC study, the expression of TTF-1, p63, cytokeratins 5/6 were positive, while there were no expression of thyroglobulin with its positive reaction in the thyroid tissue. Additional histochemical staining with Alcian blue revealed a positive reaction with a homogeneous acellular substance of the tumor. A comprehensive morphological study with the use of additional stains made it possible to accurately establish the diagnosis, which will determine the further tactics of managing the patient.

• Authors: A Yu Abrosimov, E V Bondarenko, D A Pastuhova, M E Beloshitsky
• Journal: Arkhiv patologii (Arkh Patol) Vol. 85 Issue 6 Pg. 47-51 ( 2023) ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Skleroziruyushchii mukoepidermoidnyi rak shchitovidnoi zhelezy s eozinofiliei stromy.
• PMID: 38010638 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Female
• Humans
• Aged
• Thyroid Neoplasms (complications, diagnosis, surgery)
• Carcinoma, Mucoepidermoid (diagnosis, surgery, pathology)
• Thyroidectomy
• Eosinophilia (surgery, diagnosis, pathology)