Periostin-targeted SDSSD peptide decorated calcium phosphate nanocomposites incorporation with simvastatin for osteoporosis treatment.

Abstract

The limited options of anabolic drugs restrict their application potential in osteoporosis treatment, despite their theoretical superiority in therapeutic efficacy over antiresorptive drugs. As a prevailing strategy, nano-delivery systems could offer a wider choice of anabolic drugs. In this study, calcium phosphate nanocomposites incorporated with simvastatin (Sim) with periostin-targeting ability were designed and prepared for osteoporosis treatment. Carboxymethyl dextran (CMD) as an anionic and hydrophilic dextran derivative was used to stabilize CaP. In addition, periosteum-targeted peptide (SDSSD) was further grafted on CMD to achieve the bone targeting function. In a one-step coordination assembly strategy, hydrophobic anabolic agent Sim and SDSSD-CMD graft (SDSSD-CMD) were incorporated into the CaP nanoparticles forming SDSSD@CaP/Sim nanocomposites. The resulting SDSSD@CaP/Sim possesses uniform size, great short-term stability and excellent biocompatibility. Moreover, SDSSD@CaP/Sim exhibited a reduced release rate of Sim and showed slow-release behaviour. As anticipated, the nanocomposites exhibited bone bonding capacity in both cellular and animal studies. Besides, SDSSD@CaP/Sim achieved obviously enhanced osteoporosis treatment effect compared to direct injection of Simin vivo. Therefore, our findings highlight the potential of SDSSD-incorporated and CaP-based nanocomposites as a viable strategy to enhance the therapeutic efficacy of anabolic drugs for osteoporosis treatment.

• Authors: Zian Pan, Zhen Zhang, Xiongwei Deng, Fanqi Hu, Fan Jia, Jianqing Lu, Xuesong Zhang, Xiaoqing Yang, Yujuan Gao, Xuan Wang, Xinyue Cui, Chenlu Xu, Yan Wu
• Journal: Nanotechnology (Nanotechnology) Vol. 35 Issue 7 (Dec 01 2023) ISSN: 1361-6528 [Electronic] England
• PMID: 37976543 (Publication Type: Journal Article)
• Copyright: © 2023 IOP Publishing Ltd.

Chemical References

• Simvastatin
• Peptides
• Calcium Phosphates

Topics

• Animals
• Simvastatin (pharmacology, therapeutic use)
• Osteoporosis (drug therapy)
• Peptides (pharmacology, therapeutic use)
• Calcium Phosphates (chemistry)
• Nanocomposites (therapeutic use)