The role of dysregulated mRNA translation machinery in cancer pathogenesis and therapeutic value of ribosome-inactivating proteins.

Abstract

Dysregulated protein synthesis is a hallmark of tumors. mRNA translation reprogramming contributes to tumorigenesis, which is fueled by abnormalities in ribosome formation, tRNA abundance and modification, and translation factors. Not only malignant cells but also stromal cells within tumor microenvironment can undergo transformation toward tumorigenic phenotypes during translational reprogramming. Ribosome-inactivating proteins (RIPs) have garnered interests for their ability to selectively inhibit protein synthesis and suppress tumor growth. This review summarizes the role of dysregulated translation machinery in tumor development and explores the potential of RIPs in cancer treatment.

• Authors: Wentao Jia, Jiaying Yuan, Shu Li, Binbin Cheng
• Journal: Biochimica et biophysica acta. Reviews on cancer (Biochim Biophys Acta Rev Cancer) Vol. 1878 Issue 6 Pg. 189018 (Nov 07 2023) ISSN: 1879-2561 [Electronic] Netherlands
• PMID: 37944831 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023. Published by Elsevier B.V.