Clinical significance of surface and internal pools of platelet-associated immunoglobulins in immune thrombocytopenia.

Abstract

We have investigated serum platelet bindable IgG(SPBIgG) and platelet-associated IgG(PAIgG) in patients with immune thrombocytopenia (IT) to ascertain the significance of the larger amounts of PAIgG reported both in normals and in patients using homogenized (Total:T-PAIgG) instead of intact platelets (Surface:S-PAIgG). 12 patients, during active immune thrombocytopenia (A-IT), and 18 patients in steroid-induced remission (S-IT), were studied. As control we considered 20 patients with non-immune thrombocytopenia (N-IT) and 29 subjects with normal platelet count. The average positivity of SPBIgG was 41% with a higher percentage in A-IT (66%) than in S-IT (16%). The results of PAIgG also indicate a different behaviour in A-IT and S-IT of surface and cytoplasmatic pools. During A-IT both pools are enhanced with prevalence towards the surface one (S-PAIgG). On the contrary, during steroid-induced remission, despite the normal amount of the S-PAIgG present the internal pool still increases, indicating a steady-state of IT and the possible existence of a platelet phagocytic activity.

• Authors: F Fabris, A Casonato, M L Randi, G Luzzatto, A Girolami
• Journal: Scandinavian journal of haematology (Scand J Haematol) Vol. 37 Issue 3 Pg. 215-20 (Sep 1986) ISSN: 0036-553X [Print] Denmark
• PMID: 3787173 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin G
• Receptors, Antigen, B-Cell

Topics

• Adult
• Arthritis, Rheumatoid (complications, immunology)
• Autoimmune Diseases (immunology)
• Blood Platelets (immunology)
• Child
• Female
• Humans
• Immunoglobulin G (immunology)
• Lupus Erythematosus, Systemic (complications, immunology)
• Male
• Middle Aged
• Platelet Count
• Purpura, Thrombocytopenic (immunology)
• Receptors, Antigen, B-Cell (immunology)
• Thrombocytopenia (etiology, immunology)