Sepsis is a life-threatening organ dysfunction caused by dysregulated body response to
infection. It is also one of the major causes of death in
critically ill patients. Over the past few years, despite the continuous improvement in the treatment of
sepsis, there is no specific treatment, clinical morbidity and mortality are still rising. Therefore, finding effective methods to treat
sepsis and reduce mortality is an urgent clinical problem.
Histone modification is an epigenetic modification that produces heritable phenotypic changes without altering the DNA sequence. In recent years, many studies have shown that
histone modification is closely related to
sepsis. This review discusses the mechanism of
histone modification in the pathogenesis of
sepsis from the aspects of inflammatory factors, signaling pathways, and macrophage polarization, in aimed to provide reference for the clinical treatment of
sepsis.