Abstract |
The results of studies on the H-2 antigens expression on L1210 and P388 mouse lymphoma cells and their drug-resistant sublines as well as on Lewis lung carcinoma (LL2) cells and their wheat germ agglutinin-resistant variants (LL(2)5 and LL(2)8) are presented. The results revealed no qualitative alterations in H-2 antigens expression on cells of L1210 and P388 leukemias and their drug-resistant sublines. However, as determined by cytotoxic assay the increase relative to parental lines in the expression of normal H-2d antigens on cells of both drug-resistant sublines was observed. Using quantitative absorption assay in addition to differentiate quantitative expression of normal H-2b antigens, the presence of alien H-2k and H-2d specificities on lectin-resistant cells of Lewis lung carcinoma was detected.
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Authors | A Opolski, D Duś, C Radzikowski |
Journal | Archivum immunologiae et therapiae experimentalis
(Arch Immunol Ther Exp (Warsz))
Vol. 34
Issue 1
Pg. 21-34
( 1986)
ISSN: 0004-069X [Print] Switzerland |
PMID | 3778114
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Neoplasm
- Antigens, Surface
- H-2 Antigens
- Lectins
- Wheat Germ Agglutinins
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Topics |
- Animals
- Antigens, Neoplasm
(analysis)
- Antigens, Surface
(analysis)
- Cell Line
- Cytotoxicity Tests, Immunologic
- Drug Resistance
- H-2 Antigens
(analysis)
- Haplotypes
- Lectins
(pharmacology)
- Leukemia L1210
(immunology, pathology)
- Leukemia P388
(immunology, pathology)
- Leukemia, Experimental
(immunology)
- Lung Neoplasms
(immunology)
- Lymphoma
(immunology)
- Mice
- Mice, Inbred Strains
- Neoplasms, Experimental
(immunology, pathology)
- Wheat Germ Agglutinins
(pharmacology)
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