Somatostatin receptor subtype expression and radiomics from DWI-MRI represent SUV of [68Ga]Ga-DOTATOC PET in patients with meningioma.

Abstract

OBJECTIVE:

This retrospective study aimed to analyse the correlation between somatostatin receptor subtypes (SSTR 1-5) and maximum standardized uptake value (SUVmax) in meningioma patients using Gallium-68 DOTA-D-Phe1-Tyr3-octreotide Positron Emission Tomography ([68Ga]Ga-DOTATOC PET). Secondly, we developed a radiomic model based on apparent diffusion coefficient (ADC) maps derived from diffusion weighted magnetic resonance images (DWI MRI) to reproduce SUVmax.

METHOD:

The study included 51 patients who underwent MRI and [68Ga]Ga-DOTATOC PET before meningioma surgery. SUVmax values were quantified from PET images and tumour areas were segmented on post-contrast T1-weighted MRI and mapped to ADC maps. A total of 1940 radiomic features were extracted from the tumour area on each ADC map. A random forest regression model was trained to predict SUVmax and the model's performance was evaluated using repeated nested cross-validation. The expression of SSTR subtypes was quantified in 18 surgical specimens and compared to SUVmax values.

RESULTS:

The random forest regression model successfully predicted SUVmax values with a significant correlation observed in all 100 repeats (p < 0.05). The mean Pearson's r was 0.42 ± 0.07 SD, and the root mean square error (RMSE) was 28.46 ± 0.16. SSTR subtypes 2A, 2B, and 5 showed significant correlations with SUVmax values (p < 0.001, R2 = 0.669; p = 0.001, R2 = 0.393; and p = 0.012, R2 = 0.235, respectively).

CONCLUSION:

SSTR subtypes 2A, 2B, and 5 correlated significantly with SUVmax in meningioma patients. The developed radiomic model based on ADC maps effectively reproduces SUVmax using [68Ga]Ga-DOTATOC PET.

• Authors: Sarah Iglseder, Anna Iglseder, Vincent Beliveau, Johanna Heugenhauser, Elke R Gizewski, Johannes Kerschbaumer, Guenther Stockhammer, Christian Uprimny, Irene Virgolini, Jozsef Dudas, Meinhard Nevinny-Stickel, Martha Nowosielski, Christoph Scherfler
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 164 Issue 3 Pg. 711-720 (Sep 2023) ISSN: 1573-7373 [Electronic] United States
• PMID: 37707754 (Publication Type: Journal Article)
• Copyright: © 2023. The Author(s).

Chemical References

• Edotreotide
• Octreotide
• Receptors, Somatostatin
• Organometallic Compounds

Topics

• Humans
• Octreotide
• Meningioma (diagnostic imaging, surgery)
• Receptors, Somatostatin (analysis, metabolism)
• Retrospective Studies
• Positron-Emission Tomography (methods)
• Magnetic Resonance Imaging
• Meningeal Neoplasms (diagnostic imaging, surgery)
• Organometallic Compounds