Linezolid optic neuropathy.

Abstract

PURPOSE OF REVIEW:

In this article, we reviewed 67 reported cases of linezolid optic neuropathy and describe the common characteristics and expectations for recovery with an emphasis on recent findings in the literature.

RECENT FINDINGS:

Linezolid classically causes a reversible, duration-dependent optic neuropathy. However, in our review, we found only 66.7% of patients recovered complete visual function. Vision loss most commonly affected visual acuity followed by visual field and color vision. We also found patients taking higher doses of linezolid experienced full recovery less often, suggesting a dose-dependent component of linezolid optic neuropathy. Linezolid use has increased in frequency and duration, especially in the treatment of drug-resistant tuberculosis, and data indicate that these patients experience lower rates of complete vision recovery compared with patients taking linezolid for other indications.

SUMMARY:

Linezolid is an effective medication for treating drug-resistant infections; however, it may result in optic neuropathy. It is reasonable for patients on linezolid to undergo screening examinations, especially those on higher doses or for prolonged duration of therapy.

• Authors: H Victoria Miller, Angela A Cao, Collin M McClelland, Michael S Lee
• Journal: Current opinion in ophthalmology (Curr Opin Ophthalmol) Vol. 34 Issue 6 Pg. 481-486 (Nov 01 2023) ISSN: 1531-7021 [Electronic] United States
• PMID: 37603423 (Publication Type: Review, Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Linezolid
• Anti-Infective Agents

Topics

• Humans
• Linezolid (adverse effects)
• Optic Nerve Diseases (chemically induced, diagnosis)
• Anti-Infective Agents
• Optic Nerve
• Vision Disorders