Abstract | Background & Aims: Methods: Results: Treatment with CHP limited overall lipid accumulation, lowered systemic inflammation, and prevented hyperglycaemia. Histopathology and liver transcriptomics highlighted reduced steatosis and demonstrated remarkable protection from the development of inflammation and fibrosis, features which herald the progression of NAFLD. We identified the extracellular signal-regulated kinase (ERK) pathway as an early mediator of the cellular response to CHP. Conclusions: Impact and implications: Considering the incidence and the lack of approved treatments, it is urgent to identify new strategies that prevent and manage NAFLD. CHP was effective in attenuating NAFLD progression in two animal models of the disease. Overall, our work points to CHP as a novel and effective strategy for the management of NAFLD, fuelling optimism for potential clinical studies.
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Authors | Alessia De Masi, Xiaoxu Li, Dohyun Lee, Jongsu Jeon, Qi Wang, Seoyeong Baek, Onyu Park, Adrienne Mottis, Keno Strotjohann, Alexis Rapin, Hoe-Yune Jung, Johan Auwerx |
Journal | JHEP reports : innovation in hepatology
(JHEP Rep)
Vol. 5
Issue 9
Pg. 100815
(Sep 2023)
ISSN: 2589-5559 [Electronic] Netherlands |
PMID | 37600955
(Publication Type: Journal Article)
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Copyright | © 2023 The Authors. |