Feel so bac: is Fusobacterium the suspect causing endometriosis?

Abstract

Recent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.

• Authors: Huan-Tzu Hou, Ting-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
• Journal: Trends in molecular medicine (Trends Mol Med) Vol. 29 Issue 10 Pg. 780-782 (10 2023) ISSN: 1471-499X [Electronic] England
• PMID: 37599125 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier Ltd. All rights reserved.

Chemical References

• RNA, Ribosomal, 16S

Topics

• Animals
• Mice
• Female
• Humans
• Fusobacterium
• Base Composition
• Endometriosis (etiology)
• Phylogeny
• RNA, Ribosomal, 16S
• Sequence Analysis, DNA