Infantile Myofibromatosis With Cutaneous, Visceral, and CNS Involvement: A Multimodal Approach to Therapy.

Abstract

BACKGROUND:

Infantile myofibromatosis (IM) is a rare benign tumor of infancy. Cases with solitary and multicentric disease usually spontaneously regress, but multicentric disease with visceral involvement carries a poor prognosis. Few cases of multicentric disease with central nervous system (CNS) involvement have been reported, and none report survival.

OBSERVATIONS:

We present a newborn with multicentric IM with cutaneous, visceral, and CNS involvement. She was treated with vinblastine, methotrexate, and the novel addition of intrathecal methotrexate with treatment response after 1 year of therapy.

CONCLUSIONS:

Multicentric IM with CNS involvement can be successfully treated with a multimodal approach of chemotherapy with the addition of intrathecal methotrexate and surgery.

• Authors: Stephanie Gehle, Carolyn Quinsey, Diana McShane, Patrick Thompson, Gerardo Quezada
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 45 Issue 7 Pg. e921-e923 (10 01 2023) ISSN: 1536-3678 [Electronic] United States
• PMID: 37526359 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Methotrexate
• Vinblastine

Topics

• Infant, Newborn
• Female
• Humans
• Methotrexate (therapeutic use)
• Myofibromatosis (therapy, pathology)
• Vinblastine (therapeutic use)