Effect of renal tubular damage on non-cancer mortality in the general Japanese population living in cadmium non-polluted areas.

Abstract

This study aimed to clarify the cause-effect relationship between renal tubular damage and non-cancer mortality in the general Japanese population. We conducted a 19-year cohort study including 1110 men and 1,03 women who lived in three cadmium-non-polluted areas in 1993 or 1994. Mortality risk ratios based on urinary β2-microglobulin (β2MG) and N-acetyl-β-glucosaminidase (NAG) concentrations were estimated for specific non-cancer diseases using the Fine and Gray competing risks regression model. In men, continuous urinary NAG (+1 μg/g cre) concentrations were significantly correlated with increased mortality caused by diseases of the respiratory system (hazard ratio (HR): 1.09, 95% confidence interval (CI): 1.03-1.15). Urinary β2MG (+100 μg/g cre) concentrations were significantly correlated with increased mortalities caused by kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00-1.03), renal diseases (HR: 1.01, 95% CI: 1.00-1.03), renal failure (HR: 1.02, 95% CI: 1.00-1.03), and external causes of mortality (HR: 1.01, 95% CI: 1.00-1.02). In women, urinary NAG (+1 μg/g cre) concentrations were significantly associated with increased mortality caused by ischemic heart diseases (HR: 1.02, 95% CI: 1.00-1.04) and kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00-1.04). Urinary β2MG (+100 μg/g cre) concentrations were significantly correlated with increased mortality caused by cardiovascular diseases (HR: 1.01, 95%CI: 1.00-1.02), ischemic heart diseases (HR: 1.01, 95%CI: 1.00-1.02), and kidney and urinary tract diseases (HR: 1.02, 95% CI: 1.01-1.03). The present study indicates that renal tubular damage was significantly related to several non-cancer disease causes of mortality in Japan's general population living in cadmium-non-polluted areas.

• Authors: Sayaka Sakuma, Kazuhiro Nogawa, Yuuka Watanabe, Masaru Sakurai, Muneko Nishijo, Masao Ishizaki, Yuko Morikawa, Teruhiko Kido, Hideaki Nakagawa, Yasushi Suwazono
• Journal: Journal of applied toxicology : JAT (J Appl Toxicol) Vol. 43 Issue 12 Pg. 1849-1858 (12 2023) ISSN: 1099-1263 [Electronic] England
• PMID: 37460094 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 John Wiley & Sons, Ltd.

Chemical References

• Acetylglucosaminidase
• beta 2-Microglobulin
• Cadmium

Topics

• Female
• Humans
• Male
• Acetylglucosaminidase (urine)
• beta 2-Microglobulin (urine)
• Cadmium (toxicity, urine)
• Cohort Studies
• East Asian People
• Environmental Exposure (adverse effects, analysis)
• Kidney Diseases (chemically induced, mortality, urine)
• Myocardial Ischemia (mortality)