Ivermectin and doxycycline treatments against Onchocerciasis: Adaptations and impact among semi-nomadic population in Massangam Health District, Cameroon.

Abstract

We trialed strategies to reach semi-nomadic population with interventions targeting onchocerciasis including a combination of community knowledge and Geographical Information System (GIS) technology; nomad-specific sensitization; and mobile outreach. The interventions included ivermectin (ivm) mass drug administration (MDA) and treating infected individuals (found upon skin snip microscopy test) with doxycycline for 35 days. Microscopy-negative snips were further tested by Polymerase Chain Reaction (PCR). After 8 months, individuals immigrating or emigrating constituted 47% of the initial population; 59% of individuals not born in the area have immigrated during the last five years; 28% (age>9) reportedly never taken ivm; 72% (compared to 51% previously) of eligible population (age ≥ 5 years) took ivm; and 47% (age > 8, not pregnant, not breastfeeding, not severely ill,) participated in the test. A high prevalence of onchocerciasis,15.1%, was found upon microscopy & PCR test; 9/10 tested by skin snip microscopy and PCR at follow-up were all negative. Microfilaria prevalence and intensity upon skin snip microscopy reduced significantly from baseline following the intervention (8.9% to 4.1%, p = 0.032; 0.18 to 0.16, p = 0.013, respectively). The strategies considerably increased reach to nomadic camps. Treating with doxycycline in combination with ivm is feasible and has led to a significant reduction in infection level within one year among the semi-nomads. Being potentially curative in one intervention round, this combination should be considered for population group faced with challenges of achieving adequate coverage and adhesion to ivm MDA over prolonged period (>10 years).

• Authors: Rogers Nditanchou, Ruth Dixon, Kareen Atekem, Benjamin Biholong, Aude Wilhelm, Richard Selby, Joseph Oye, Joseph Kamgno, Daniel Boakye, Elena Schmidt, Laura Senyonjo
• Journal: PLoS neglected tropical diseases (PLoS Negl Trop Dis) Vol. 17 Issue 7 Pg. e0011463 (07 2023) ISSN: 1935-2735 [Electronic] United States
• PMID: 37437096 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright: © 2023 Nditanchou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Chemical References

• Ivermectin
• Doxycycline

Topics

• Female
• Humans
• Pregnancy
• Child
• Child, Preschool
• Ivermectin (therapeutic use)
• Onchocerciasis (drug therapy)
• Doxycycline (therapeutic use)
• Cameroon (epidemiology)
• Mass Drug Administration
• Prevalence