Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis.

Abstract

OBJECTIVE:

We aimed to analyze the predictive efficacy of amniotic fluid interleukin-6 (IL-6) and neutrophil gelatinase-associated lipocalin (NGAL) for fetal inflammatory response syndrome (FIRS)-related infection.

MATERIALS AND METHODS:

We included singleton pregnancies classified into FIRS and non-FIRS groups. FIRS was defined as histologic chorioamnionitis and funisitis. Amniotic fluid samples were collected during vaginal delivery (VD) or cesarean section (CS). We compared amniotic fluid IL-6 and NGAL levels between the groups.

RESULTS:

Forty-six pregnancies were analyzed and classified into 20 (43.5%) FIRS and 26 (56.5%) non-FIRS pregnancies. We observed significant differences in amniotic fluid IL-6 and NGAL. Amniotic fluid collection significantly influenced NGAL levels (p < 0.001). The area under the concentration-time curve (AUC), with optimal cutoff values, for amniotic fluid IL-6 and NGAL (VD and CS) levels was 0.948 (11,344 pg/mL), 0.800 (1180 ng/mL), and 0.946 (708 ng/mL), respectively.

CONCLUSION:

Amniotic fluid IL-6 and NGAL levels showed equivalent predictive ability for FIRS-related infection.

• Authors: Daisuke Katsura, Shunichiro Tsuji, Kaori Hayashi, Shinsuke Tokoro, Takako Hoshiyama, Nobuyuki Kita, Takashi Murakami
• Journal: Taiwanese journal of obstetrics & gynecology (Taiwan J Obstet Gynecol) Vol. 62 Issue 4 Pg. 516-520 (Jul 2023) ISSN: 1875-6263 [Electronic] China (Republic : 1949- )
• PMID: 37407186 (Publication Type: Journal Article)
• Copyright: Copyright © 2023. Published by Elsevier B.V.

Chemical References

• Interleukin-6
• Lipocalin-2

Topics

• Pregnancy
• Humans
• Female
• Chorioamnionitis (diagnosis)
• Interleukin-6
• Amniotic Fluid
• Lipocalin-2
• Cesarean Section