Zn(II) porphyrin-encapsulated MIL-101 for photodynamic therapy of breast cancer cells.

Abstract

The photodynamic treatment is a non-aggressive and clinically accepted procedure for removing selected cancer cells with the activation of a photosensitizer agent at a specific light. In this study, the zinc porphyrin (Zn[TPP]) was prepared and encapsulated into the MIL-101 (Zn[TPP]@MIL-101). It was used in photodynamic therapy (PDT) against MCF-7 breast cancer cells under a red light-emitting diode. The structure, morphology, surface area, and compositional changes were investigated using conventional characterization methods including FTIR, FESEM, EDX, and BET analyses. The MTT assay was performed under light and dark conditions to explore the ability of Zn[TPP]@MIL-101 in PDT. The results have demonstrated the IC50 of 14.3 and 81.6 mg/mL for light and dark groups, respectively. As the IC50 revealed, the Zn[TPP]@MIL-101 could efficiently eradicate cancer cells using PDT.

• Authors: Samaneh Hashemi Ghoochani, Hasan Ali Hosseini, Zahra Sabouri, Mohammad Hasan Soheilifar, Hoda Keshmiri Neghab, Alireza Hashemzadeh, Mahin Velayati, Majid Darroudi
• Journal: Lasers in medical science (Lasers Med Sci) Vol. 38 Issue 1 Pg. 151 (Jun 28 2023) ISSN: 1435-604X [Electronic] England
• PMID: 37378703 (Publication Type: Journal Article)
• Copyright: © 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

Chemical References

• Porphyrins
• MIL-101
• Photosensitizing Agents
• Zinc

Topics

• Humans
• Female
• Porphyrins (therapeutic use)
• Photochemotherapy (methods)
• Breast Neoplasms (drug therapy)
• Photosensitizing Agents (therapeutic use)
• Zinc (pharmacology, therapeutic use)
• Cell Line, Tumor