Abstract | AIM: Previous studies have evaluated the pulpal responses to calcium silicate cements (CSCs) on normal dental pulp, but investigations on the effects of CSCs on inflamed pulp are limited. This study aimed to test the inflammatory response and odontogenic differentiation of inflamed rat dental pulp after direct pulp capping with CSCs. METHODOLOGY: RESULTS: After 4 weeks, complete recovery from inflammation was evident in 22%, 37.5%, 10% and none of the ProRoot MTA, Biodentine, RetroMTA and Dycal samples, respectively. Heavy hard tissue deposition as a continuous hard tissue bridge was observed in 77.8%, 75%, 70% and 60% of the ProRoot MTA, Biodentine, RetroMTA and Dycal samples, respectively. IL-6, OCN and RUNX2 were detected in all materials, mainly adjacent to areas of inflammation and reparative dentine formation. At one, two and 4 weeks, significant differences were not observed between the inflammation and hard tissue formation scores of the four material groups (p > .05). CONCLUSIONS: In this study, pulpal inflammation was still present in most specimens at 4 weeks after pulp capping and a significant number of samples showed incomplete and discontinuous dentine bridge formation. The results of this study suggest that initial inflammatory conditions of the pulp may risk the prognosis of teeth treated with CSCs.
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Authors | M Chung, S Lee, S Kim, E Kim |
Journal | International endodontic journal
(Int Endod J)
Vol. 56
Issue 9
Pg. 1118-1128
(Sep 2023)
ISSN: 1365-2591 [Electronic] England |
PMID | 37350351
(Publication Type: Journal Article)
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Copyright | © 2023 British Endodontic Society. Published by John Wiley & Sons Ltd. |
Chemical References |
- Aluminum Compounds
- Calcium Compounds
- CMW cement
- Core Binding Factor Alpha 1 Subunit
- Drug Combinations
- Dycal
- Osteocalcin
- Oxides
- Pulp Capping and Pulpectomy Agents
- Silicates
- tricalcium silicate
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Topics |
- Animals
- Rats
- Aluminum Compounds
(pharmacology, therapeutic use)
- Calcium Compounds
(pharmacology, therapeutic use)
- Core Binding Factor Alpha 1 Subunit
- Dental Pulp
- Dental Pulp Capping
(methods)
- Drug Combinations
- Inflammation
(therapy)
- Osteocalcin
- Oxides
(pharmacology, therapeutic use)
- Pulp Capping and Pulpectomy Agents
(pharmacology, therapeutic use)
- Rats, Wistar
- Silicates
(pharmacology, therapeutic use)
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