Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report.

Abstract

BACKGROUND:

Biomedical applications of electroporation are expanding out of the field of oncology into vaccination, treatment of arrhythmias and now in the treatment of vascular malformations. Bleomycin is a widely used sclerosing agent in the treatment of various vascular malformations. The application of electric pulses in addition to bleomycin enhances the effectiveness of the drug, as demonstrated by electrochemotherapy, which utilizes bleomycin in the treatment of tumors. The same principle is used in bleomycin electrosclerotherapy (BEST). The approach seems to be effective in the treatment of low-flow (venous and lymphatic) and, potentially, even high-flow (arteriovenous) malformations. Although there are only a few published reports to date, the surgical community is interested, and an increasing number of centers are applying BEST in the treatment of vascular malformations. Within the International Network for Sharing Practices on Electrochemotherapy (InspECT) consortium, a dedicated working group has been constituted to develop standard operating procedures for BEST and foster clinical trials.

CONCLUSIONS:

By treatment standardization and successful completion of clinical trials demonstrating the effectiveness and safety of the approach, higher quality data and better clinical outcomes may be achieved.

• Authors: Tobian Muir, Giulia Bertino, Ales Groselj, Lakshmi Ratnam, Erika Kis, Joy Odili, Ian McCafferty, Walter A Wohlgemuth, Maja Cemazar, Aljosa Krt, Masa Bosnjak, Alessandro Zanasi, Michela Battista, Francesca de Terlizzi, Luca G Campana, Gregor Sersa
• Journal: Radiology and oncology (Radiol Oncol) Vol. 57 Issue 2 Pg. 141-149 (06 01 2023) ISSN: 1581-3207 [Electronic] Poland
• PMID: 37341196 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 Tobian Muir et al., published by Sciendo.

Chemical References

• Bleomycin

Topics

• Humans
• Electrochemotherapy
• Vascular Malformations
• Electroporation Therapies
• Electroporation
• Bleomycin (therapeutic use)