Genomic Analysis of a Linezolid-Resistant Staphylococcus capitis Causing Bacteremia: Report from a University Hospital in Central Italy.

Abstract

Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant Staphylococcus capitis in a patient previously treated with linezolid. Whole genome sequencing revealed the common mutation G2576T in all rDNA 23S alleles and several acquired resistance genes. Moreover, the isolate was epidemiologically distant from the NRCS-A clade, usually responsible for nosocomial infections in neonatal intensive care units. Our findings further confirm the ability of minor staphylococci to acquire antibiotic resistances and challenge the treatment of these infections.

• Authors: Lucia Brescini, Simona Fioriti, Sonia N Coccitto, Marzia Cinthi, Marina Mingoia, Oscar Cirioni, Andrea Giacometti, Eleonora Giovanetti, Gianluca Morroni, Andrea Brenciani
• Journal: Microbial drug resistance (Larchmont, N.Y.) (Microb Drug Resist) Vol. 29 Issue 9 Pg. 388-391 (Sep 2023) ISSN: 1931-8448 [Electronic] United States
• PMID: 37222764 (Publication Type: Journal Article)

Chemical References

• Linezolid
• Anti-Bacterial Agents
• Coagulase

Topics

• Infant, Newborn
• Humans
• Linezolid (pharmacology, therapeutic use)
• Staphylococcus capitis
• Anti-Bacterial Agents (pharmacology)
• Methicillin-Resistant Staphylococcus aureus
• Staphylococcal Infections (drug therapy)
• Coagulase (genetics)
• Microbial Sensitivity Tests
• Staphylococcus (genetics)
• Bacteremia (drug therapy)
• Genomics
• Hospitals