Oxidative stress is one of the hallmarks of
cancer.
Tumorigenesis and progression are accompanied by elevated
reactive oxygen species (ROS) levels and adaptive elevation of
antioxidant expression levels.
Peroxiredoxins (PRDXs) are among the most important
antioxidants and are widely distributed in a variety of
cancers. PRDXs are involved in the regulation of a variety of
tumor cell phenotypes, such as invasion, migration, epithelial-mesenchymal transition (EMT) and stemness. PRDXs are also associated with
tumor cell resistance to cell death, such as apoptosis and ferroptosis. In addition, PRDXs are involved in the transduction of hypoxic signals in the TME and in the regulation of the function of other cellular components of the TME, such as cancer-associated fibroblasts (CAFs), natural killer (NK) cells and macrophages. This implies that PRDXs are promising targets for
cancer treatment. Of course, further studies are needed to realize the clinical application of targeting PRDXs. In this review, we highlight the role of PRDXs in
cancer, summarizing the basic features of PRDXs, their association with
tumorigenesis, their expression and function in
cancer, and their relationship with
cancer therapeutic resistance.