We present the case of a 76-year-old male patient persistently infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the setting of a stage IIIC cutaneous
melanoma and
non-Hodgkin's lymphoma (NHL). Due to the persistent
coronavirus disease 19 (COVID-19), all
cancer treatments were discontinued. Because of the worsening of his clinical state and the persistence of SARS-CoV-2 positivity for more than six months, the patient was treated with
sotrovimab, which was ineffective due to resistance mutations acquired during that time. In order to resume
cancer treatment and make the patient free from SARS-CoV-2, an in vitro screening of
Evusheld monoclonal antibodies (tixagevumab-
cilgavimab) against the viral strains isolated from the subject was performed. The promising results obtained during in vitro testing led to the authorization of the
off-label use of
Evusheld, which made the patient negative for SARS-CoV-2, thus, allowing him to resume his
cancer treatment. This study highlights the
Evusheld monoclonal antibodies' efficacy, not only in prevention but also in successful therapy against prolonged
COVID-19. Therefore, testing neutralizing
monoclonal antibodies in vitro against SARS-CoV-2 mutants directly isolated from patients could provide useful information for the treatment of people affected by
long COVID.