Abstract | BACKGROUND: METHODS: We retrospectively evaluated 73 consecutive patients who underwent hepatectomy for CRLM, and assessed the relationship between their preoperative autotaxin levels and SOS. RESULTS: Median autotaxin level was 0.750 mg/L. Preoperative oxaliplatin-based chemotherapy for CRLM was administered to 51 patients, and SOS was histologically observed in 45 patients. Patients who received the oxaliplatin-based chemotherapy had significantly higher autotaxin levels than those who did not (p = 0.038). Furthermore, autotaxin levels were higher in patients with SOS than in those without (p = 0.011). Univariate and multivariate analyses revealed that autotaxin level can be an independent predictive factor for SOS preoperatively (p = 0.001). CONCLUSIONS: Autotaxin level is a noninvasive and promising surrogate marker for predicting SOS before surgical resection for CRLM.
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Authors | Norihiro Ishii, Norifumi Harimoto, Takaomi Seki, Ryo Muranushi, Kei Hagiwara, Mariko Tsukagoshi, Akira Watanabe, Yuka Yoshida, Kenichiro Araki, Ken Shirabe |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 53
Issue 8
Pg. 761-770
(Aug 2023)
ISSN: 1386-6346 [Print] Netherlands |
PMID | 36946410
(Publication Type: Journal Article)
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Copyright | © 2023 Japan Society of Hepatology. |