Abstract | Introduction: Materials and Methods: Forty-eight patients who were matched for age, gender, COVID-19 disease severity, and respiratory support type and needed high flow nasal cannula, non-invasive mechanical ventilator, or invasive mechanical ventilator due to COVID-19 were followed up prospectively. Eighteen patients were excluded from the follow-up due to known structural lung disease, collagen tissue disease, and occupational exposure to fibrosis. The patients were called for follow-up three months after discharge, and CT was performed. Those with fibrosis (n= 15) in the third-month follow-up CT were included in the CAPF group, and those with complete resolution (n= 15) were included in the control group. Blood samples were taken for genetic analysis. Result: TERT gene study revealed that six (40%) of the fibrosis group was normal, while five were heterozygous (33.3%). MUC5B polymorphism was not detected in 10 (66.7%) of the fibrosis group. Conclusions: Individuals with TERT mutations may be at a higher risk for CAPF. Further studies are needed to clarify the genetic risk factors for CAPF.
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Authors | Nur Aleyna Yetkin, Aslıhan Kiraz, Burcu Baran Ketencioğlu, Canan Bol, Nuri Tutar |
Journal | Tuberkuloz ve toraks
(Tuberk Toraks)
Vol. 71
Issue 1
Pg. 34-40
(Mar 2023)
ISSN: 2980-3187 [Electronic] Turkey |
Vernacular Title | MUC5B ve TERT mutasyonları şiddetli COVID-19 olan bireylerde pulmoner fibrozis için genetik risk faktörleri midir? |
PMID | 36912407
(Publication Type: Journal Article)
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Chemical References |
- MUC5B protein, human
- Mucin-5B
- TERT protein, human
- Telomerase
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Topics |
- Mucin-5B
(genetics)
- Telomerase
(genetics)
- Humans
- COVID-19
(complications, genetics, pathology)
- Pulmonary Fibrosis
(genetics)
- Middle Aged
- Male
- Female
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