Helicobacter pylori Infection as a Predictor of Treatment Outcomes of Gastric Cancer: A Systematic Review and Meta-Analysis.

Abstract

BACKGROUND:

Helicobacter pylori infection is strongly associated with gastric cancer. However, there is currently no consensus on the association between H. pylori and gastric cancer prognosis.

METHODS:

A systematic search was conducted on studies in PubMed, EMBASE, and Web of Science up to March 10, 2022. The quality of all included studies was assessed using the Newcastle-Ottawa Scale. The hazard ratio (HR) and its 95% confidence interval (95% CI) were extracted to analyze the association between H. pylori infection and prognosis of gastric cancer. In addition, subgroup analysis and publication bias were performed.

RESULTS:

A total of 21 studies were involved. The pooled HR was 0.67 (95% CI, 0.56-0.79) for overall survival (OS) in H. pylori-positive patients, with the control (HR = 1) being the H. pylori-negative group. In the subgroup analysis, the pooled HR was 0.38 (95% CI, 0.24-0.59) for OS in H. pylori-positive patients who received surgery combined with chemotherapy. The pooled HR for disease-free survival was 0.74 (95% CI, 0.63-0.8) and 0.41 (95% CI, 0.26-0.65) in patients who received surgery combined with chemotherapy.

CONCLUSION:

H. pylori-positive gastric cancer patients have a better overall prognosis than H. pylori-negative patients. H. pylori infection has improved the prognosis of patients undergoing surgery or chemotherapy, among which the improvement was most obvious in patients undergoing surgery combined with chemotherapy.

• Authors: Chenxiao Gan, Xueping Wu, Yu Shen, Zhongsheng Cao, Jiyong Jing, Wensheng Pan
• Journal: Digestive diseases (Basel, Switzerland) (Dig Dis) Vol. 41 Issue 4 Pg. 553-564 ( 2023) ISSN: 1421-9875 [Electronic] Switzerland
• PMID: 36907179 (Publication Type: Meta-Analysis, Systematic Review)
• Copyright: © 2023 S. Karger AG, Basel.

Topics

• Humans
• Stomach Neoplasms (therapy)
• Helicobacter pylori
• Helicobacter Infections (complications, drug therapy)
• Treatment Outcome
• Prognosis