Surgical excision of solid
tumors is required for local control of
neoplasms. However, surgical
trauma can stimulate the release of proangiogenic
growth factors, suppressing cell-mediated immunity and favoring the development of
micrometastases and progression of residual disease. The present study aimed to evaluate the intensity of the metabolic response to
trauma induced via unilateral
mastectomy in bitches with mammary
neoplasia, the consequences of its joint performance with ovariohysterectomy, and their respective effects on the organic response. Two groups of animals were evaluated in seven perioperative moments, namely, unilateral
mastectomy (G1) and unilateral
mastectomy associated with ovariohysterectomy (G2). Thirty-two female dogs were selected, ten clinically healthy, and twenty-two diagnosed with mammary
neoplasia. Surgical
trauma reduced serum concentrations of
albumin and
interleukin-2 but increased blood levels of
glucose and
interleukin-6 in the postoperative of G1 and G2 patients. Moreover, serum
cortisol levels increased after unilateral
mastectomy associated with ovariohysterectomy. Our findings allowed us to conclude that unilateral
mastectomy induces significant metabolic alterations in female dogs with
mammary neoplasms and its joint performance with ovariohysterectomy increases the organic response to
trauma.