Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment.

Abstract

Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid-liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.

• Authors: Konjeti R Sekhar, Michael L Freeman
• Journal: Cancer research (Cancer Res) Vol. 83 Issue 10 Pg. 1573-1580 (05 15 2023) ISSN: 1538-7445 [Electronic] United States
• PMID: 36877156 (Publication Type: Review, Journal Article)
• Copyright: ©2023 The Authors; Published by the American Association for Cancer Research.

Chemical References

• Nucleophosmin
• Nuclear Proteins

Topics

• Humans
• Nucleophosmin
• Nuclear Proteins (genetics, metabolism)
• Mutation
• DNA Damage
• DNA Repair
• Leukemia, Myeloid, Acute (therapy, drug therapy)