Peptides, which are important components of the human body, appear in different chemistry applications. Perhaps the most important of these applications is the use of these structures in drug delivery systems due to their biocompatibility properties.
Diphenylalanine (FF)
peptide-based systems, which are part of the ß-
amyloid polypeptide sequence and are known as the smallest
dipeptide group, are particularly preferred due to their biocompatible nature, thermal stability, high ionic strength in water in new targeted
drug systems.
Epirubicin, the epimer of
doxorubicin, is utilized in treating
lung cancer. The side effects and the applied doses of
epirubicin are being tried to be reduced. Therefore, in this study,
epirubicin-loaded tert-butyloxycarbonyl protected
diphenylalanine (Boc)-FF particles were synthesized and characterized and the effects of these
peptides on cytotoxicity, genotoxicity, oxidative stress and apoptosis on
non-small cell lung cancer cells (NSCLC) (A549) were evaluated. According to the results of the study, it was determined that
epirubicin-loaded Boc-FF
dipeptides significantly reduced the viability, oxidative stress, and increased DNA damage and apoptosis in the cells. The study suggests that
epirubicin-loaded Boc-FF particles can be used as an alternative
drug carrier for NSCLC treatment due to their physiological, chemical, and
biological activity.