Abstract |
Spermine (Spm) and spermidine (Spmd) are considered as potential biomarker for early diagnosis of human cancer. Herein, a novel acyclic cucurbituril derivative (UL-ACB) was firstly designed and synthesized, which fluoresces at 460 nm after excitation at 365 nm. UL-ACB is rich in oxygen atoms which are capable of forming coordinate bonds with copper (Cu2+) that cause quenching of UL-ACB fluorescence. Moreover, the addition of biological endogenous substances Spm and Spmd can turn on fluorescence of UL-ACB. Interestingly, the probe showed a remarkable detection efficiency for Spm and Spmd in human urine (the detection limits of Spm and Spmd were 0.156 μM and 0.762 μM, and the linear ranges are 0.156 ∼ 43.06 μM and 0.762 ∼ 29.10 μM), which completely covered the early diagnosis of urinary Spm (1 ∼ 10 μM) and urine Spmd (1 ∼ 20 μM) required concentration range in cancer patients. The probe for Spm and Spmd is simple, time-saving and selective, which may provide a new promising strategy for early cancer diagnosis.
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Authors | Shuqing Zhang, Liyuan Chen, Chao Zhou, Chuanzhu Gao, Jing Yang, Xiali Liao, Bo Yang |
Journal | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
(Spectrochim Acta A Mol Biomol Spectrosc)
Vol. 294
Pg. 122515
(Jun 05 2023)
ISSN: 1873-3557 [Electronic] England |
PMID | 36842211
(Publication Type: Journal Article)
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Copyright | Copyright © 2023. Published by Elsevier B.V. |
Chemical References |
- Fluorescent Dyes
- Spermidine
- Spermine
- Copper
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Topics |
- Humans
- Fluorescent Dyes
(chemistry)
- Spermidine
- Spermine
- Neoplasms
(diagnosis)
- Copper
(chemistry)
- Spectrometry, Fluorescence
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