A nomogram prediction of citrate reaction during mononuclear cell collection in solid tumor patients.

Abstract

PURPOSE:

Citrate reaction is one of the main adverse events in peripheral blood mononuclear cell (MNC) collection. The aim of this study was to elucidate the risk factors for citrate reaction in patients with advanced solid tumor collection and to construct a nomogram to predict the risk.

METHODS:

One hundred forty-eight patients with advanced solid tumor who underwent peripheral blood MNC collection in our hospital between January 2021 to December 2021 were selected. The general data, creatinine level before collection, Ca2+ concentration before collection, absolute value of monocyte lymphocytes before collection, circulating blood volume, anticoagulant dosage, and blood collection duration were included in Logistic regression analysis to identify the risk factors of citrate reaction. According to the results of the multivariate logistic model, nomogram was established and receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of the model.

RESULTS:

Among the 148 solid tumor patients, 35 patients (23.6%) of the 148 patients developed citrate reaction. Multivariate analysis showed that the risk factors for citrate reaction in the process of collection included sex (odds ratio [OR] = 6.718; 95% confidence interval [95% CI]: 2.191-20.594, P = .001), age (OR = 0.957; 95% CI: 0.921-0.996, P = .03), and processed circulating blood volume (OR = 1.001; 95% CI: 1.000-1.002, P = .01). Logistic regression can analyze independent risk factors and establish risk prediction model. The predictive performance of the model is good, and the area under ROC curve is 0.799.

CONCLUSIONS:

The MNC collection process is safe. The incidence of citrate reaction in the collection of peripheral blood MNCs from patients with advanced solid tumor is related to the age, gender, and processed circulating blood volume of patients. The nomogram can be used to assess a patient's risk of citrate reaction.

• Authors: Yong Xia, Hui Xue, Jing Li, Yanyan Yu, Wei Huang, Chuchu Zhou, Tingting Shi, Yanxia Cheng, Caihong Zhang, Shuang Liu, Zongchang Song, Sha Xu, Jinxing Lou
• Journal: Journal of clinical apheresis (J Clin Apher) Vol. 38 Issue 4 Pg. 422-426 (Aug 2023) ISSN: 1098-1101 [Electronic] United States
• PMID: 36760009 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors. Journal of Clinical Apheresis published by Wiley Periodicals LLC.

Chemical References

• Citric Acid
• Citrates

Topics

• Humans
• Nomograms
• Leukocytes, Mononuclear
• Citric Acid (adverse effects)
• Retrospective Studies
• Neoplasms (drug therapy)
• Citrates