Abstract | PURPOSE: METHODS: RESULTS: Between 1994 and 2017, a total of 108 patients were included. Median ages were 43 years and 51 years for patients receiving MAP and AP, respectively. The 5‑year local relapse-free survival (LRFS), disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) were 94.1, 63.6, 75.3, and 71.9%, respectively. In the multivariate analysis, significant predictors were identified as follows: de novo or R1/R2 resected tumor on admission before RCT (p = 0.017; hazard ratio [HR] 0.112, 95% confidence interval [CI] 0.019-0.675) and R0 resection after RCT (p = 0.010; HR 0.121, 95% CI 0.024-0.598) for LRFS; female gender (p = 0.042; HR 0.569, 95% CI 0.330-0.979) and liposarcoma histology (p = 0.014; HR 0.436, 95% CI 0.224-0.845) for DFS; liposarcoma histology (p = 0.003; HR 0.114, 95% CI 0.027-0.478) and AP regimen (p = 0.017; HR 0.371, 95% CI 0.165-0.836) for DSS; age ≤ 45 years (p = 0.043; HR 0.537, 95% CI 0.294-0.980) and liposarcoma histology (p = 0.006; HR 0.318, 95% CI 0.141-0.716) for OS, respectively. CONCLUSION: An increased risk for local failure seems to exist for patients with relapsed tumor on admission and having positive surgical margins after neoadjuvant RCT. Intensity of chemotherapy influenced DSS but not OS, which could be due to younger patients receiving MAP.
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Authors | Ugur Yilmaz, Serra Kamer, Huseyin Kaya, Dundar Sabah, Ulus Ali Sanli, Ipek Tamsel, Banu Yaman, Taner Akalin, Yavuz Anacak |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 199
Issue 6
Pg. 585-594
(06 2023)
ISSN: 1439-099X [Electronic] Germany |
PMID | 36725697
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. |
Chemical References |
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Topics |
- Female
- Humans
- Adult
- Middle Aged
- Cisplatin
- Neoplasm Recurrence, Local
(pathology)
- Sarcoma
(therapy, pathology)
- Extremities
(pathology)
- Soft Tissue Neoplasms
(surgery)
- Doxorubicin
- Liposarcoma
(drug therapy, pathology)
- Neoadjuvant Therapy
- Chemoradiotherapy
- Retrospective Studies
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