Abstract | BACKGROUND: METHODS: Serum samples were collected to detect ITIH4 by enzyme-linked immunosorbent assay in 127 sepsis patients at admission (baseline), day (D)1, D3, and D7 after admission, as well as in 30 healthy controls (HCs). Additionally, 28-day mortality was recorded in sepsis patients. RESULTS: ITIH4 was reduced in sepsis patients versus HCs (median [interquartile range]: 147.9 [78.2-208.8] vs. 318.8 [237.2-511.4] ng/ml) (p < 0.001). In sepsis patients, ITIH4 was associated with the absence of cardiovascular and cerebrovascular disease history (p = 0.021). Additionally, ITIH4 was negatively correlated with tumor necrosis factor-α (p < 0.001), interleukin (IL)-1β (p < 0.001), IL-6 (p = 0.019), IL-17A (p = 0.002), and C-reactive protein (p = 0.001), but positively related to IL-10 (p = 0.007). Moreover, ITIH4 was also inversely associated with Acute Physiology and Chronic Health Evaluation II score (p = 0.002), Sequential Organ Failure Assessment (SOFA) score (p < 0.001), SOFA-respiratory system score (p = 0.023), and SOFA-renal system score (p = 0.007). Interestingly, ITIH4 gradually increased from baseline to D7 (p < 0.001); besides, ITIH4 at baseline (p = 0.009), D1 (p = 0.002), D3 (p < 0.001), and D7 (p = 0.015) were all decreased in sepsis deaths versus sepsis survivors. CONCLUSION: Serum ITIH4 is raised from baseline to D7 after disease onset, and it reflects the reduction of systemic inflammation, disease severity, and 28-day mortality for sepsis. However, further verification is required.
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Authors | Xiangwang Zhao, Yong Guo, Lingyu Li, Yusheng Li |
Journal | Journal of clinical laboratory analysis
(J Clin Lab Anal)
Vol. 37
Issue 3
Pg. e24834
(Feb 2023)
ISSN: 1098-2825 [Electronic] United States |
PMID | 36725250
(Publication Type: Journal Article)
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Copyright | © 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. |
Chemical References |
- Alpha-Globulins
- Cytokines
- inter-alpha-inhibitor
- ITIH4 protein, human
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Topics |
- Humans
- Alpha-Globulins
- Cytokines
- Inflammation
- Multiple Organ Failure
- Prognosis
- Sepsis
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