[Combined effect of interferon inducers, radiosensitizing and antineoplastic agents on solid tumors].

Abstract

In experiments with mice bearing solid sarcoma 37 a study was conducted on the combined effect of radiation and inductors of endogenous interferon synthesis (IEIS), together with hyperthermia or together with an alkylating and carbomoilating agent, dimethinur. The effect was estimated by the tumor growth coefficient and by the number of animals with the regressed tumors. Po I. polyC was not shown to influence the efficiency of hyperthermia combined with radiation; dextransulphate and tiloron increased the radiosensitizing effect of hyperthermia. Dimethinur aggravated the effect of radiation, but with IEIS used together with dimethynur and radiation, the response of the tumor increased insignificantly as compared to the effect of IEIS together with radiation.

• Authors: D L Leonidze
• Journal: Radiobiologiia (Radiobiologiia) 1987 Sep-Oct Vol. 27 Issue 5 Pg. 696-9 ISSN: 0033-8192 [Print] Russia (Federation)
• Vernacular Title: Sovmestnoe deĭstvie induktorov sinteza interferona, radiosensibiliziruiushchikh i protivoopukholevykh agentov na solidnye opukholi.
• PMID: 3671688 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Interferon Inducers
• Radiation-Sensitizing Agents

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Combined Modality Therapy
• Hyperthermia, Induced
• Interferon Inducers (therapeutic use)
• Mice
• Mice, Inbred Strains
• Radiation-Sensitizing Agents (therapeutic use)
• Sarcoma 37 (therapy)
• Sarcoma, Experimental (therapy)