Enhanced In Vivo Radiotherapy of Breast Cancer Using Gadolinium Oxide and Gold Hybrid Nanoparticles.

Abstract

Radiation therapy has demonstrated promising effectiveness against several types of cancers. X-ray radiation therapy can be made further effective by utilizing nanoparticles of high-atomic-number (high-Z) materials that act as radiosensitizers. Here, in purpose of maximizing the radiation therapy within tumors, bovine serum albumin capped gadolinium oxide and gold nanoparticles (Gd2O3@BSA-Au NPs) are developed as a bimetallic radiosensitizer. In this study, we incorporate two high-Z-based nanoparticles, Au and Gd, in a single nanoplatform. The radiosensitizing ability of the nanoparticles was assessed with a series of in vitro tests, following evaluation in vivo in a breast cancer murine model. Enhanced tumor suppression is observed in the group that received radiation after administration of Gd2O3@BSA-Au NPs. As a result, cancer therapy efficacy is significantly improved by applying Gd2O3@BSA-Au NPs under X-ray irradiation, as evidenced by studies evaluating cell viability, proliferation, reactive oxygen species production, and in vivo anti-tumor effect.

• Authors: Hamed Nosrati, Marziyeh Salehiabar, Jalil Charmi, Kadir Yaray, Mohammadreza Ghaffarlou, Esra Balcioglu, Yavuz Nuri Ertas
• Journal: ACS applied bio materials (ACS Appl Bio Mater) Vol. 6 Issue 2 Pg. 784-792 (02 20 2023) ISSN: 2576-6422 [Electronic] United States
• PMID: 36693820 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gadolinium
• gadolinium oxide
• Gold
• Radiation-Sensitizing Agents
• Serum Albumin, Bovine

Topics

• Animals
• Mice
• Gadolinium (therapeutic use)
• Gold (pharmacology, therapeutic use)
• Metal Nanoparticles (therapeutic use)
• Neoplasms
• Radiation-Sensitizing Agents (pharmacology, therapeutic use)
• Serum Albumin, Bovine
• Breast Neoplasms (radiotherapy)