Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review.

Abstract

Gastric cancer (GC) is a common gastrointestinal tumor. Gastric precancerous lesions (GPL) are the last pathological stage before normal gastric mucosa transforms into GC. However, preventing the transformation from GPL to GC remains a challenge. Traditional Chinese medicine (TCM) has been used to treat gastric disease for millennia. A series of TCM formulas and active compounds have shown therapeutic effects in both GC and GPL. This article reviews recent progress on the herbal drugs and pharmacological mechanisms of TCM in preventing the transformation from GPL to GC, especially focusing on anti-inflammatory, anti-angiogenesis, proliferation, and apoptosis. This review may provide a meaningful reference for the prevention of the transformation from GPL to GC using TCM.

• Authors: Yi-Lin Zhong, Peng-Qian Wang, Dan-Li Hao, Feng Sui, Feng-Bin Zhang, Bing Li
• Journal: World journal of gastrointestinal oncology (World J Gastrointest Oncol) Vol. 15 Issue 1 Pg. 36-54 (Jan 15 2023) ISSN: 1948-5204 [Print] China
• PMID: 36684050 (Publication Type: Journal Article, Review)
• Copyright: ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.