Gender-specific effects of capsiate supplementation on body weight and bone mineral density: a randomized, double-blind, placebo-controlled study in slightly overweight women.

Abstract

INTRODUCTION:

Overweight and obesity are highly prevalent conditions associated with premature morbidity and mortality worldwide. Capsiate, a nonpungent analogue of capsaicin, binds to TRP vanilloid 1 (TRPV1) receptor, which is involved in adipogenesis, and could be effective as a weight-lowering agent.

METHODS:

Eighteen slightly overweight women were enrolled in this randomized, double-blind, placebo-controlled study. Nine patients were included in the capsiate intervention group and received 9 mg/day of capsinoids and 9 patients received placebo for 8 weeks. All patients underwent weight and waist circumference assessment before and after treatment. Body composition and bone mineral density (BMD) were also detected by dual-energy X-ray absorptiometry (DXA).

RESULTS:

Fourteen patients completed the study. The treatment with capsiate or placebo for 8 weeks was not associated with significant changes in weight or waist circumference. After treatment, there was a significant improvement in BMD values measured at the spine in the capsiate group (1.158 vs 1.106 g/cm2, + 4.7%; p = 0.04), but not in the group treated with placebo. Similarly, the capsiate group showed a 9.1% increase (p = 0.05) in the adipose tissue and an 8.5% decrease in lean mass measured at the supraclavicular level, whereas these changes were not statistically significant in the placebo group.

CONCLUSIONS:

Treatment with capsiate for 8 weeks led to negligible changes in body weight in a small sample of slightly overweight women, but our findings suggest a potential effect of capsaicin on bone metabolism in humans.

• Authors: G Salvio, M Petrelli, S Paolini, V Baldini, C Sbaffi, S Basili, A Giordano, G Balercia, S Cinti
• Journal: Journal of endocrinological investigation (J Endocrinol Invest) Vol. 46 Issue 7 Pg. 1415-1422 (Jul 2023) ISSN: 1720-8386 [Electronic] Italy
• PMID: 36609773 (Publication Type: Randomized Controlled Trial, Journal Article)
• Copyright: © 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).

Chemical References

• capsiate
• Capsaicin

Topics

• Humans
• Female
• Capsaicin (pharmacology)
• Bone Density
• Overweight
• Dietary Supplements
• Double-Blind Method