No difference in follow-up estimated glomerular filtration rate between hypertensive and matched nonhypertensive kidney donors.

Abstract

BACKGROUND:

According to current guidelines, kidney donor candidates with controlled hypertension using 1 or 2 antihypertensive drugs may be considered as donor. However, this recommendation is based on the study that antihypertensive drug was initiated in mainly "after donor registration" and this may be white-coat hypertension because of donation-related anxiety. We compared the follow-up eGFR between kidney donors with preexisting hypertension and matched nonhypertensive donors.

METHODS:

This single-center retrospective study classified 97 living hypertensive donors previously receiving antihypertensive drugs into two groups: 1 drug group (61 donors) and 2 drugs group (36 donors). We compared the follow-up eGFR between each donor previously receiving antihypertensive drugs and three matched nonhypertensive donors in terms of age, sex, and follow-up duration.

RESULTS:

At a mean (range) of 51 months (12-214) in the 1 drug group, and 54 months (12-175) in the 2 drugs group after donation, there was no significant difference in follow-up eGFR between hypertensive donors previously receiving antihypertensive drugs and matched controls in each group and in total donors. There was no difference in the incidence of the patients with follow-up eGFR<45mL/min/m2 in each group and their matched controls. Multiple linear regression analysis showed that baseline eGFR was the only independent predictor for the final follow-up eGFR in the total donors.

CONCLUSION:

Our results support the current guidelines that donor candidates with controlled hypertension using 1 or 2 antihypertensive drugs may be considered as donors, and may increase the strength of this recommendation.

• Authors: Eun Hye Yang, Sung Shin, Young Hoon Kim, In Gab Jeong, Bumsik Hong, Chung Hee Baek, Hyosang Kim, Soon Bae Kim
• Journal: Nefrologia (Nefrologia (Engl Ed)) (Dec 06 2022) ISSN: 2013-2514 [Electronic] Spain
• PMID: 36494286 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier España, S.L.U.