Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives.

Abstract

Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure-activity relationship based on the available information.

• Authors: Marcos Lorca, David Cabezas, Ileana Araque, Andrés Terán, Santiago Hernández, Marco Mellado, Luis Espinoza, Jaime Mella
• Journal: Steroids (Steroids) Vol. 190 Pg. 109153 (02 2023) ISSN: 1878-5867 [Electronic] United States
• PMID: 36481216 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Brassinosteroids
• Plant Growth Regulators
• Steroids, Heterocyclic

Topics

• Humans
• Brassinosteroids (pharmacology)
• Plant Growth Regulators (pharmacology)
• Structure-Activity Relationship
• Neoplasms (drug therapy)
• Steroids, Heterocyclic (pharmacology)