The gene cell migration inducing
hyaluronidase 1 (CEMIP) is on chromosome 15q25 and codes for a 150-kDa
protein with an N-terminal secretion signal, a G8 domain, 2 GG domains, and several repeats. It was first described as a specific
protein in the inner ear relating to
nonsyndromic hearing loss. Recently, increasing research detected its association in various
cancers, determining the progression,
metastasis, and prognosis by influencing the proliferation and invasion of the cells. This relation is accomplished through various interacting pathways, such as the Wnt/β-
catenin signaling pathway and the
epidermal growth factor receptor signaling pathway. Thus, CEMIP could be a novel and potential focus for
tumor diagnosis and treatment, but further studies on the regulatory role of CEMIP in vivo and in vitro are still needed. Herein, we summarize the process in recent studies of CEMIP, especially in
cancer research.