Abstract | BACKGROUND: CASE REPORT: A 44-year-old woman with a history of depression ingested 3.0 g of amoxapine during a suicide attempt. Although she was initially treated with intravenous diazepam, her seizures persisted. Levetiracetam and phenobarbital were then administered, but seizures persisted. Hence, ILE was injected for over 1 min. At 2 min after ILE administration, the patient's status seizures ceased. Recurrence of seizures was observed 30 min after ILE, and the seizures disappeared after re-administration of ILE. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: ILE may be effective in amoxapine intoxication. Emergency physicians may consider ILE as an adjunctive therapy for amoxapine poisoning with a high mortality rate. ILE should be implemented carefully with monitoring of total dosage and adverse events.
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Authors | Masaru Matsuoka, Toru Imai, Sou Iwabuchi, Kosaku Kinoshita |
Journal | The Journal of emergency medicine
(J Emerg Med)
Vol. 64
Issue 1
Pg. 62-66
(Jan 2023)
ISSN: 0736-4679 [Print] United States |
PMID | 36450616
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Amoxapine
- Fat Emulsions, Intravenous
- Diazepam
- Antidepressive Agents, Second-Generation
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Topics |
- Female
- Humans
- Adult
- Amoxapine
(adverse effects)
- Fat Emulsions, Intravenous
- Seizures
(chemically induced)
- Suicide, Attempted
- Diazepam
- Antidepressive Agents, Second-Generation
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