Hand-foot syndrome (HFS) can be categorized as a frequent dose-limiting side effect following administration of chemotherapeutic agents, which needs an effective medication to avoid
dose reduction or discontinuation. Oral
celecoxib has been proved to be the best pharmacological intervention to ameliorate the skin lesions. However, due to reported gastrointestinal and cardiovascular toxicity following its long-term administration,
celecoxib topical application would be a safe alternative for skin disorders. In this work, first, we formulated and optimized a topical
hydrogel of
celecoxib (1%) and then we investigated its efficacy in the management of
chemotherapy-induced HFS in
cancer patients. Optimized
hydrogel showed acceptable results for
drug content, pH, rheology, and stability. Analyzing in vitro drug release study by various mathematical models, the optimized
hydrogel showed a zero-order release pattern with 93.27 ± 1.56% cumulative
celecoxib release within 8 h. Ex vivo permeation studies across Wistar rat skin indicated suitable skin retention of
celecoxib for topical delivery. Twenty-nine patients suffering from HFS were randomized to receive
celecoxib and the placebo
hydrogels 2 times a day for 3 weeks. At the baseline and at the end of the trial, HFS grades were determined. No serious adverse events occurred in patients who completely followed the instructions. No statistically significant differences between two arms were observed at the baseline (p value = 0.38). By contrast, Wilcoxon signed-rank test showed significant differences when secondary grades (p value = 0.05) and grade differences (p values < 0.001) were analyzed. Overall, the study proved that
celecoxib hydrogel could be a promising intervention to manage HFS side effect.